Panax ginseng, merkezi kolinerjik ve dopaminerjik meka- nizmalarla etki gösteren ve sildenafil içeren bitkisel bir ilaçtır. Erektil disfonksiyon tedavisinde yaygın. erektil disfonksiyon (ED) medikal tedavisindeki moleküler ve klinik düzeyde ortaya konulan yenilikler incelenecektir. Melanosit stimüle edici hormonun santral. düzenli CPAP tedavisi ile ortadan kalkabilmektedir. Anahtar kelimeler: Apne hipopne indeksi, erektil disfonksiyon, obstruktif uyku apne sendromu. ABSTRACT .
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Erektil disfonksiyon, farmakoterapi, sildenafil, vardenafil, tadalafil ABSTRACT Erectile dysfunction ED is a common medical condition that affects the sexual life of millions of men and increases in frequency with time. Introduction of the phosphodiesterase inhibitors has revolutionized the management of this common problem, encouraging many more men to seek treatment. The higher cGMP levels, therefore, act as amplifiers of the normal erectile physiology and are dependent on intact libido, sexual stimulation.
At present, first-line oral pharmacotherapy for most patients with ED is a phosphodiesterase type 5 PDE-5 inhibitor, of which three are currently available worldwide: Sildenafil, vardenafil and tadalafil.
All three PDE 5 inhibitors are effective in most men with erectile dysfunction in the general population and in select populations, such as men with diabetes mellitus, and patients who have had nerve-sparing radical prostatectomy.
Tadalafil has a longer duration of action than sildenafil and vardenafil. None of these PDE inhibitors should be used more than once a day. Men who take nitrate-based drugs such as nitroglycerin for heart problems should not use either drugs because the combination can cause a sudden drop in blood pressure. This review describes the pharmacologic and clinical features of the PDE 5 inhibitors and the other oral agents in the first-line treatments of ED.
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Erektil Disfonksiyon Tedavisinde Birinci Basamak Oral Farmakoterapi | Article | Türkiye Klinikleri
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